Welcome to Group of Gene Medical Formulation and Engineering (Xin Zhang¡¯s Group), National Key Laboratory of Biochemical Engineering
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Xin ZHANG
Professor, PI
National Key Laboratory of Biochemical Engineering
Institute of Process Engineering
Chinese Academy of Sciences, 100190, Beijing, P. R. China
Tel: (+86) 10 8254 4853
Fax: (+86) 10 8254 4853
Email: xzhang@ipe.ac.cn
Group Website: http://www.gmfe-ipe.cn

Research Interest:
Biomaterials; Drug delivery; Diagnostic imaging; Vaccine adjuvant; Stem cell therapy

Education:
2004 008: Ph.D. in Life Science: University of Strasbourg, FRANCE
2001 2004: M.S. in Materials: Tianjin University, CHINA
1997 2001: B.S. in Polymer Materials: Tianjin University, CHINA

Professional Experience:
2010 Present: Professor, Institute of Process Engineering, Chinese Academy of Sciences, CHINA
2008 2010: Assistant Professor, INSERM, FRANCE

Contributions within Five Years:
More than 40 research papers published in peer-reviewed journals, including Advanced Materials, Nano Letters, Theranostics, Biomaterials, and Journal of Controlled Release, which have been cited overall more than 500 times; one Chinese Book chapter entitled "Gene therapy drug mimetic membrane system" and one English Book chapter entitled " Lipopolyplex nanoparticles for tumor targeting theranostics " published at 2013 by Science Press, China, and 2014 by Higher Education Press, China, respectively; 10 patents.

Professional Affiliations:
Membership: American Chemical Society
Committee Membership: Chinese Society for Biomaterials
Committee Membership: Chinese Society of Biomedical Engineering

Selected Publications within Five Years:
[1] Deng Heng, Dai Fengying, Ma Guanghui, Zhang Xin*. Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance. Advanced Materials, 2015, DOI: 10.1002/adma.201501420
[2] Hu Bingbing, Dai Fengying, Fan Zhanming, Ma Guanghui, Zhang Xin*. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer’s Disease in APPswe/PS1dE9 Transgenic Mice. Advanced Materials, 2015, Accepted.
[3] Li Yan, Liu Ruiyuan, Yang Jun, Shi Yuanjie, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior. Biomaterials, 2015, 41: 1-14.
[4] Li Yan, Liu Ruiyuan, Yang Jun, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy. Biomaterials, 2014, 35, 9731-9745.
[5] Liu Hongmei, Li Yan, Mozhi Anbu, Zhang Liang, Liu Yilan, Xu Xia, Xing Jianmin, Liang Xingjie, Ma Guanghui, Yang Jun*, Zhang Xin*. SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment. Biomaterials, 2014, 35: 6519-6533.
[6] Yang Jun, Liu Hongmei, Zhang Xin*. Design, Preparation and application of nucleic acid delivery carriers. Biotechnology Advances, 2014, 32: 804-817.
[7] Li Yan, Cheng Qiang, Jiang Qian, Huang Yuanyu, Liu Hongmei, Zhao Yuliang, Cao Weipeng, Ma Guanghui, Dai Fengying, Liang Xingjie, Liang Zicai, Zhang Xin*. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. Journal of Controlled Release, 2014, 176: 104-114.
[8] Li Yan, Liu Ruiyuan, Shi Yuanjie, Zhang Zhenzhong*, Zhang Xin*. Zwitterionic poly(carboxybetaine) based cationic liposomes enhancing tumor therapy without accelerated blood clearance phenomenon. Theranostics, 2015, 5: 583-596.
[9] Deng Heng, Zhong Yanqi, Du Meihong, Liu Qingjun, Fan Zhanming*, Dai Fengying*, Zhang Xin*. Theranostic self-Assembly structure of gold nanoparticles for NIR photothermal therapy and X-ray computed tomography imaging. Theranostics, 2014, 4: 904-918.
[10]Zhang Xin, Sharma Kamal Kant, Boeglin Marcel, Ogier Joelle, Mainard Didier, Voegel Jean-Claude, Mely Yves*, Benkirane-Jessel Nadia*. Transfection ability and intracellular DNA pathway of nanostructured gene-delivery systems. Nano Letters, 2008, 8: 2432-2436.
[11]Zhang Xin, Oulad-Abdelghani Mustapha, Zelkin Alexander, Wang Yajun, Haikel Youssef, Mainard Didier, Voegel Jean-Claude, Caruso Frank*, Benkirane-Jessel Nadia*. Poly(L-lysine) nanostructured particles for gene delivery and hormone stimulation. Biomaterials, 2010, 31: 1699-1706.
[12]Zhang Xin, Kovtun Anna, Mendoza-Palomares Carlos, Oulad-Abdelghani Mustapha, Fioretti Florence, Rinckenbach Simon, Mainard Didier, Epple Matthias, Benkirane-Jessel Nadia*. SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing. Biomaterials, 2010, 31: 6013-6018.